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Posted on 05-03-2012

Dr. Russell Greene was a coauthor of a recent article in the journal, Clinical and Vaccine Immunology (March 2012), entitled "Evaluation of Coccidioides Antigen Detection in Dogs with Coccidioidomycosis". Since Coccidioides antigen detection has been reported to be a promising method for rapid diagnosis of Valley Fever (coccidioidomycosis) in humans, it was hoped that the same would prove true in dogs. The Coccidioides antigen test, which can be run on serum and urine, was tested on 60 dogs that had been diagnosed with Valley Fever, based on detection of anti-Coccidioides antibodies at titers of 1:16 or more in serum. Several control populations of dogs were also evaluated, including dogs with presumed histoplasmosis or blastomycosis, other fungal infections, or nonfungal diseases and healthy dogs. It was concluded that detection of Coccidioides antigen in dog serum and/or urine was an insensitive method for diagnosis of Valley Fever in this study.
A follow-up study is currently in progress, evaluating the Coccidioides antigen test in dogs with a proven diagnosis of Valley Fever, based upon histopathology, cytology, or fungal culture results.

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